After defeating the evil pirate LeChuck, Guybrush Threepwood inadvertently infects the entire Caribbean with an unleashed voodoo spirit that threatens to turn pirates into uncontrollable monsters. Pursued by an infamous pirate hunter and a creepy French doctor who believes that the secret to eternal life lies in Guybrush’s creepily infected hand, Threepwood sails the seven seas in search of La Esponja Grande, a legendary sea sponge with unrivaled voodoo-cleansing powers. But Guybrush doesn’t know it yet, but his quest is part of a larger, more sinister conspiracy, and good and evil are not always as they seem…
Who can Guybrush trust? Where can he turn? Everything you think you know will be called into question as Tales of Monkey Island comes to an unexpected conclusion!